Mounjaro® (tirzepatide) is a once-weekly injectable that works on two metabolic hormone pathways—GIP and GLP-1.
By enhancing insulin regulation, reducing appetite, and slowing digestion, it helps patients achieve significant and sustained weight loss when combined with lifestyle measures.
How it works
GLP-1 (Glucagon-Like Peptide-1): slows digestion, reduces appetite, and increases the feeling of fullness.
GIP (Glucose-Dependent Insulinotropic Polypeptide): improves insulin efficiency and enhances the weight-loss effects of GLP-1.
Together, these two pathways provide a dual mechanism of action.
Clinical trials have shown tirzepatide can achieve greater and more sustained weight loss than many earlier weight management medications, making it one of the most effective medical options studied to date.
Does it work?
Large clinical trials in people with overweight or obesity (without diabetes) have shown impressive results:
SURMOUNT-1: After 72 weeks, average weight loss was about 15% at 5 mg, 19.5% at 10 mg, and over 20% at 15 mg, compared with 3% on placebo.
SURMOUNT-3: People who first did an intensive lifestyle program, then added tirzepatide, lost even more weight compared to lifestyle alone.
SURMOUNT-4 (withdrawal study): Patients who stopped Mounjaro regained much of the weight, while those who continued maintained or improved their results—showing that ongoing treatment is key for sustained benefit.
Latest studies: Research has shown Mounjaro delivers greater average weight loss than many earlier weight management medications, making it one of the most effective medical tools currently available.
How is it taken?
Injection: Once weekly under the skin.
Dose: Start low (2.5 mg weekly for 4 weeks), then gradually increase every month depending on tolerance and doctor’s guidance.
Step-up schedule: Helps reduce side effects such as nausea.
Safety and Side Effects
Common: nausea, vomiting, diarrhea, constipation—usually mild to moderate and improve over time.
Possible risks: gallbladder issues, pancreatitis, dehydration-related kidney problems.
Not suitable for: people with a personal/family history of medullary thyroid carcinoma or MEN2, during pregnancy, or with certain severe GI diseases.
Drug interactions: may require adjustment of other diabetes medications to prevent hypoglycemia.
Why medical supervision matters
Mounjaro is highly effective, but not a “magic pen.” Safe and lasting results require:
Baseline tests (blood sugar, cholesterol, kidney, liver, hormones)
Doctor-supervised titration of dose
Lifestyle integration (nutrition, exercise, sleep)
Ongoing follow-up to monitor side effects and prevent weight regain
At PrimeCare, our weight management program combines Mounjaro therapy with continuous doctor support, so patients achieve results that are safe, sustainable, and personalized.
Bottom line
Mounjaro has changed the landscape of weight management by delivering some of the most effective results seen to date.
With proper supervision and lifestyle support, it offers patients not only weight reduction but also long-term health benefits.
